1. CONFIRM THAT THE INDIVIDUAL LAYERS ARE IN FACT PRODUCING INDEPENDENT AND BONA-FIDE P-VALUES To be safe, perform network permutations before, not after, computation of prevalence score Confirm that results DO NOT CHANGE when performing these permutations
2. Consider using Fisher combined p-value
3. THINK ABOUT HOW TO SYSTEMATICALLY VALIDATE A PARTICULAR METHOD ASSOCIATED WITH A LAYER Cross validation procedure